Role of genotype in chemical induced cancers

1. The Committee has finished a major project to investigate whether there is any evidence that the genetic code for individuals (genotype) is important in determining the risk of cancer due to exposure to chemicals. The Committee concluded that so far there was no consistent or strong interaction between the genotype of an individual and chemical induced cancer. However the Committee could not discount the possibility that important interactions would not be discovered in the future. It was important to keep this subject under review particularly in the light of the expected developments from the USA (The Environmental Genome Project) and other intiatives.

2. A lay summary of the statement is available for those who are non-technical.

3. A full statement is available for professionals.

4. Relevant papers are also available as background information.

CC/01/3 - Criteria for the design of gene-environment epidemiology studies

CC/01/3 Table for CC/01/3

CC/01/4 - A review of potential target genes for susceptibility to carcinogenesis

CC/01/5 - A review of how gene-environment studies should be used in risk assessment process

June 2002

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