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The Committee aims to publish papers where appropriate (except items
where data was provided in confidence). These papers have been drafted
by the secretariat and do not necessarily represent the veiws of the Committee
or government departments. The papers are published without the appended
references which are subject to copyright of the publishing journals.
Working Papers will be replaced when final versions are available
WP Draft Minutes 
of meeting held on ....
2008
MUT/08/1
- Review of Genotoxicity of Acrylamide: Review of additional data December
2007 and January 2008 from PPG
MUT/08/2 annex1t1
annex1t2 add1
- Overview of genotoxicity of acrylamide since 1995
MUT/08/3
- Review of COM guidance: Discussion paper on scope and process
MUT/08/4
- Draft working paper on mutagenicity assessment of chemical mixtures
MUT/08/6
- Additional data on acrylamide
MUT/08/7
- Overview of genotoxicity of glycidamide
MUT/08/8
- Review of genotoxicity data on phenol
MUT/08/9
- Generic papers on hypothermia and hyperthermia and induction of MN in
rodent
MUT/08/10
- Mutagenicity evaluation of impurities
MUT/08/11
- Scope of review of COM guidance
MUT/08/12
- Consideration of draft ICH guidance
Top
2007
MUT/07/01
- Formaldehyde: Evidence for systemic mutagenicity
MUT/07/02
- The Lowest Effective Dose (LED for in-vivo genotoxicity);
a possible approach to mutagen potency ranking
MUT/07/03
- Initial discussion paper on mutagenicity of mixtures
MUT/07/04
- Benzimidazoles: an approach to defining a common aneugenic grouping
MUT/07/05
- Paper for information only
MUT/07/06
- Strategies for mutagenicity testing post 7th Amendment to the EU
Cosmetics Directive. Discussion of commentary paper from Tweats DJ et
al published Mutagenesis, 2 Dec 2006
MUT/07/07
- Draft Annual report for 2006
MUT/07/8
- Use of the LED for potency ranking of in-vivo mutagens
MUT/07/9
- Mutagenicity of Terephthalic acid - Additional cytogenetics data
MUT/07/10
- Additional summary information on GADD45a-GFP assay
MUT/07/11
- Development of an OECD guideline for the in-vitro Micronucleus assay
MUT/07/12
- Draft working paper on Formaldehyde (written comments)
MUT/07/14
Presentation
- The TK6 GADD45a-GFP Genotoxicity assay Dr R Walmsley (University of
Manchester)
MUT/07/15
- Mutagenicity of mixtures. 2nd discussion paper. Evaluation of interactions
using mutagenicity tests
MUT/07/16
;
annex 2
and annex 4
- Review of Submission from PPG
MUT/07/17
and annex A
- EU Risk Assessment Summary and Overview of the COM review strategy
MUT/07/18
- Toxicogenomics: Update on 2004
MUT/07/19
- Horizon scanning
MUT/07/20
- Aneuploidy: Action both oncogenically and as a tumour suppressor
MUT/07/22
- Revised code of practice for observers
MUT/07/23
- Sodium Benzoate and Potassium Sorbater
MUT/07/24
- Draft statement on Terephthalic Acid
Top
2006
MUT/06/1
; Annex 1
; Annex 2
--
Background variation in Micronuclei in peripheral blood lymphocytes;
Discussion paper on risk factors
MUT/06/2
- Biological Effects of Wear Debris Generated from
Metal on Metal Bearing Surfaces: Evidence for Genotoxicity
MUT/06/3
- A comparison of the sensitivities of the in vivo rat liver UDS assay
with the in vivo COMET assay
MUT/06/8
- Benzimidazoles: Discussion of a common mechanism group (Annex
1 in confidence)
MUT/06/9
- Terephthalic acid: Update on mutagenicity data
(Annexes A - E in confidence)
MUT/06/10
- Comparative risk assessment: Initial discussions
MUT/06/11
- Discussion of risk factors for background variance of cytogenticity
in Peripheral Blood Lymphocytes
MUT/06/14
- Benzimidazoles - Conclusions
MUT/06/15
- Role of methylation status: Transgenerational effects of methylation
MUT/06/16
- Comparative risk assessment update of COC
discussion
MUT/06/17
- Do dose response thresholds exist for genotoxic alkylating agents? GJS
Jenkins et al Mutagenesis, 20, (6), 389-398,
2005. Evidence for practical thresholds for clastogenic agents.
MUT/06/19
- Horizon scanning 2006
MUT/06/20
- 10.1 Revised procedure for holding committee meetings in open session
MUT/06/21
- Draft working paper on use of in-vivo rat liver UDS assay compared to
rat liver COMET assay data
MUT/06/22
- Risk factors affecting the formation of chromosomal aberration and micronuclei
in peripheral blood lymphocytes. Draft working paper and additional data
Top
2005
MUT/05/1- Further information
and follow-up of October 2004 review
(Annex VI)
MUT/05/3 - Mutagenicity
of Halonitromethanes
MUT/05/4 - Development
of cII transgenic mutation assay.
Comparison with lacI and lacZ systems
MUT/05/6 - Submitted
papers for February 2005 meeting MUT/05/6add1
MUT/05/6add2
MUT/05/7
-Papers for information: -
Brian Q et al, Occ Environ Med 61, 999-1005, 2004;
Votano J R et al, Mutagenesis, vol 19, 365-377, 2004 & Yamazaki
Y et al, Mutation Research, 562, 151-162, 2004.
MUT/05/9 - Cumulative
exposure
MUT/05/10 - Post February
2005 meet;selection of studies for review
MUT/05/11
- Epidemiology overview of selected studies
MUT/05/11add
MUT/05/12
Table
- Discussion paper on evaluation of positive studies & control data
MUT/05/14
- Mutagenicity data on PFOS and PFOA
MUT/05/15
- Mutagenicity data on nanomaterials
MUT/05/16
- Draft working paper on mutagenicity of Halonitromethanes
MUT/05/17
- Draft working paper on cII transgenic mutation assay
MUT/05/18
- COT/COC/COM overview of nanomaterial toxicology
Top
2004
MUT/04/1
- Update on joint COT/COC/COM meeting October 2001
MUT/04/2
- Application to mechanism of benzene induced leukaemia
MUT/04/3
- Genotoxic carcinogens and DNA repair at low doses: Advice from COM
MUT/04/4
- Significance of paper by Thilly on environmental Mutagens
MUT/04/5
- Draft OECD guideline on in-vitro micronucleus test: Use of cell
or culture as statistical unit?
MUT/04/8
- 2,3-Dichloropropan-2-ol: consideration of new mutagenicity data
MUT/04/9 - Holding Committee
meetings in open session - experience of COT
MUT/04/11 - Toxicogenomics:
additional data
MUT/04/12 - Malachite
green: consideration of new data
MUT/04/13 - SCCNFP Recommendations
on testing cosmetic ingredients for mutagenicity
MUT/04/14 - Genotoxic
carcinogens and DNA repair at low doses
annex 1
MUT/04/19 - Biomonitoring
studies from EU of genotoxicity in pesticides applicators
, annex I
, annex II
, annex III
, annex IV
and annex V
MUT/04/20 -
Review of biomonitoring studies from Croatia
MUT/04/21 - Reassessment
of toxicological testing of tobacco products
MUT/04/22 - Horizon
scanning
Top
2003
MUT/03/8
- Horizon scanning
MUT/03/9
- 2-Phenylphenol: update on mutagenicity
MUT/03/12
- Mammalian Cell Mutation Assays
MUT/03/13
- Strategy for Investigating Germ Cell Mutagens
MUT/03/14
- Mutagenicity of Chromium Picolinate
Top
2001
MUT/01/6
- 1,3 Dichloropropanol
MUT/01/7
- 2,3 Dichloropropanol
Guidance on a strategy for testing of chemicals
for mutagenicity
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