Scientific Pandemic Influenza Advisory Committee (SPI)




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Review of evidence base

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Review of the evidence base underpinning clinical countermeasures and risk from H5N1

Under the auspices of the Scientific Advisory Group on Pandemic Influenza, several scientific papers were developed in 2006, dealing with the clinical countermeasures and the risk of a pandemic originating from an H5N1 virus.

The antivirals and vaccine papers were produced with help from the MHRA.

The antibiotics paper consists of a cover note setting the scene and published clinical guidelines from a working group with input from the Department of Health, British Thoracic Society, British Infection Society and the Health Protection Agency.

These were sent to additional national and international scientific reviewers in early 2007. Revised papers were then reviewed at a colloquium, convened by the Secretary of State for Health, of national and international scientific experts in April 2007. Comments from the colloquium were incorporated into a further revision of the papers. These were again submitted to the Scientific Advisory Group and received final endorsement as reflecting a comprehensive and state of the art summary as of June 2007.

Download the papers in Portable Document Format

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